The reported death toll has risen to at least 111, according to Reuters, with local reports giving potentially higher preliminary figures.
Widespread structural damage has been reported, including collapsed buildings and damage to hospitals and other infrastructure in affected cities.
Cali, Pereira, Armenia and Manizales are among the areas reporting serious impacts; Cali reportedly suffered significant casualties and injuries.
Aftershocks continue: Reuters reported 21 aftershocks by Monday night, with authorities warning that additional tremors are possible.
Colombia's government has declared a national state of emergency and is prioritizing rescue and response operations.
The earthquake was also felt in Bogotá and neighboring countries, including Venezuela.
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